In this paper, we give a new method for solving large scale problems. The basic idea of this method depends on implementing the conjugate gradient as a corrector into a continuation method. We use the ...

In this paper we test different conjugate gradient (CG) methods for solving largescale unconstrained optimization problems. The methods are divided in two groups: the first group includes five basic ...

A San Diego biotech has set out to solve the formula for best-in-class antibody-drug conjugates, raising $120 million with support from Big Pharma Merck & Co. to fuel its efforts. Solve Therapeutics’ ...

Water-soluble polymers conjugated to proteins and anticancer drugs are in routine clinical use and clinical development as both single agents and components of combination therapy. This is ...

Figure 1: Structures of drugs and mAb-drug conjugates. AE and MMAE are highly stable molecules. There were no signs of compound degradation after 16 d in buffered saline at 37 °C. Furthermore, there ...